Valproic Acid Causes Redox-Regulated Post-Translational Protein Modifications That Are Dependent upon P19 Cellular Differentiation States

• Main Authors: Ted B. Piorczynski (Author), Jouber Calixto (Author), Haley C. Henry (Author), Kelli England (Author), Susannah Cowley (Author), Jackson M. Hansen (Author), Jonathon T. Hill (Author), Jason M. Hansen (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Valproic acid (VPA) is a common anti-epileptic drug and known neurodevelopmental toxicant. Although the exact mechanism of VPA toxicity remains unknown, recent findings show that VPA disrupts redox signaling in undifferentiated cells but has little effect on fully differentiated neurons. Redox imbal...