Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism

• Main Authors: Pengfei Liu (Author), Matthew Dodson (Author), Hui Li (Author), Cody J. Schmidlin (Author), Aryatara Shakya (Author), Yongyi Wei (Author), Joe G.N. Garcia (Author), Eli Chapman (Author), Pawel R. Kiela (Author), Qing-Yu Zhang (Author), Eileen White (Author), Xinxin Ding (Author), Aikseng Ooi (Author), Donna D. Zhang (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: NRF2, a transcription factor that regulates cellular redox and metabolic homeostasis, plays a dual role in human disease. While it is well known that canonical intermittent NRF2 activation protects against diabetes-induced tissue damage, little is known regarding the effects of prolonged...