Optimization, and in vitro and in vivo evaluation of etomidate intravenous lipid emulsion

• Main Authors: Dandan Geng (Author), Yan Li (Author), Chunyan Wang (Author), Bo Ren (Author), Heping Wang (Author), Chensi Wu (Author), Yirong Zhang (Author), Linlin Zhao (Author), Ligang Zhao (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this investigation was to develop an etomidate intravenous lipid emulsion (ETM-ILE) and evaluate its properties in vitro and in vivo. Etomidate (ETM) is a hydrophobic drug, and organic solvents must be added to an etomidate injectable solution (ETM-SOL) to aid dissolution, that causes var...