7S,15R-Dihydroxy-16S,17S-Epoxy-Docosapentaenoic Acid, a Novel DHA Epoxy Derivative, Inhibits Colorectal Cancer Stemness through Repolarization of Tumor-Associated Macrophage Functions and the ROS/STAT3 Signaling Pathway

• Главные авторы: Lifang Wang (Автор), Hack Sun Choi (Автор), Yan Su (Автор), Binna Lee (Автор), Jae Jun Song (Автор), Yong-Suk Jang (Автор), Jeong-Woo Seo (Автор)
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• Опубликовано: MDPI AG, 2021-09-01T00:00:00Z.
• Предметы: article
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Colorectal cancer is a highly malignant cancer that is inherently resistant to many chemotherapeutic drugs owing to the complicated tumor-supportive microenvironment (TME). Tumor-associated macrophages (TAM) are known to mediate colorectal cancer metastasis and relapse and are therefore a promising...