Fragile Treg cells: Traitors in immune homeostasis?

• Main Authors: Xiyu Song (Author), Ruo Chen (Author), Jiaxin Li (Author), Yumeng Zhu (Author), Jianhua Jiao (Author), Hongjiao Liu (Author), Zhinan Chen (Author), Jiejie Geng (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Regulatory T (Treg) cells play a key role in maintaining immune tolerance and tissue homeostasis. However, in some disease microenvironments, Treg cells exhibit fragility, which manifests as preserved FoxP3 expression accompanied by inflammation and loss of immunosuppression. Fragile Treg cells are...