IL-1 Mediates Tissue-Specific Inflammation and Severe Respiratory Failure in COVID-19

• Main Authors: Georgios Renieris (Author), Eleni Karakike (Author), Theologia Gkavogianni (Author), Dionysia-Eirini Droggiti (Author), Emmanouil Stylianakis (Author), Theano Andriopoulou (Author), Victoria-Marina Spanou (Author), Dionyssios Kafousopoulos (Author), Mihai G. Netea (Author), Jesper Eugen-Olsen (Author), John Simard (Author), Evangelos J. Giamarellos-Bourboulis (Author)
• Format: Book
• Published: Karger Publishers, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute respiratory distress syndrome (ARDS) in COVID-19 has been associated with catastrophic inflammation. We present measurements in humans and a new animal model implicating a role in danger-associated molecular patterns. Calprotectin (S100A8/A9) and high-mobility group box 1 (HMGB1) were measured...