siRNA Targeting PDE5A Partially Restores Vascular Damage Due to Type 1 Diabetes in a Streptozotocin-Induced Rat Model

• Main Authors: Vanessa Giselle Garcia-Rubio (Author), Sandra Edith Cabrera-Becerra (Author), Sergio Adrian Ocampo-Ortega (Author), Citlali Margarita Blancas-Napoles (Author), Vivany Maydel Sierra-Sánchez (Author), Rodrigo Romero-Nava (Author), Rocío Alejandra Gutiérrez-Rojas (Author), Fengyang Huang (Author), Enrique Hong (Author), Santiago Villafaña (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diabetes mellitus is a metabolic disease that can produce different alterations such as endothelial dysfunction, which is defined as a decrease in the vasodilator responses of the mechanisms involved such as the nitric oxide (NO) pathway. The overexpression of PDE5A has been reported in diabetes, wh...