De novo UNC13B mutation identified in a bipolar disorder patient increases a rare exon‐skipping variant

• Main Authors: Takumi Nakamura (Author), Kotori Jimbo (Author), Kazuo Nakajima (Author), Takashi Tsuboi (Author), Tadafumi Kato (Author)
• Format: Book
• Published: Wiley, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aim We previously performed the first trio‐based exome study for bipolar disorder and identified 71 de novo mutations. Among these mutations, the only mutation located at the splice donor site was in UNC13B. We focused on and analyzed the functions of the mutation. Methods In order to analy...