Endonasal CNS Delivery System for Blood-Brain Barrier Impermeant Therapeutic Oligonucleotides Using Heterotopic Mucosal Engrafting

• Main Authors: Grishma Pawar (Author), Neha N. Parayath (Author), Aditya A. Sharma (Author), Carlos Coito (Author), Olga Khorkova (Author), Jane Hsiao (Author), William T. Curry (Author), Mansoor M. Amiji (Author), Benjamin S. Bleier (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The most significant obstacle in the treatment of neurological disorders is the blood-brain barrier (BBB), which prevents 98% of all potential neuropharmaceuticals from reaching the central nervous system (CNS). Brain derived neurotrophic factor (BDNF) is one of the most intensely studied targets in...