Model Informed-Development of Amorphous Systems (MI-DAS) - an in-silico polymer selection tool for ASD development

• Ngā kaituhi matua: Elen Roberts (Author), Sadiyah Rahman (Author), Shajee Ahmed (Author), Harri Dickinson (Author), Parmesh Gajjar (Author), Talbir Austin (Author), Shanoo Budhdeo (Author), Marcel de Matas (Author), Paul Stott (Author)
• Hōputu: Pukapuka
• I whakaputaina: University of Huddersfield Press, 2023-12-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Forming amorphous solid dispersions (ASDs) is one method for improving the solubility and subsequent absorption of poorly-water soluble drugs. An ASD is a matrix of a poorly water-soluble compound with a hydrophilic polymer carrier, which stabilises the drug in its amorphous form. The choice of poly...