Structure optimization and molecular dynamics studies of new tumor-selective s-triazines targeting DNA and MMP-10/13 for halting colorectal and secondary liver cancers

• Main Authors: Christine A. Morcos (Author), Nesreen S. Haiba (Author), Rafik W. Bassily (Author), Marwa M. Abu-Serie (Author), Amira F. El-Yazbi (Author), Omar A. Soliman (Author), Sherine N. Khattab (Author), Mohamed Teleb (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of triazole-tethered triazines bearing pharmacophoric features of DNA-targeting agents and non-hydroxamate MMPs inhibitors were synthesized and screened against HCT-116, Caco-2 cells, and normal colonocytes by MTT assay. 7a and 7g surpassed doxorubicin against HCT-116 cells regarding potenc...