BAFF mediates splenic B cell response and antibody production in experimental Chagas disease.

• Main Authors: Daniela A Bermejo (Author), María C Amezcua-Vesely (Author), Carolina L Montes (Author), María C Merino (Author), Ricardo C Gehrau (Author), Hugo Cejas (Author), Eva V Acosta-Rodríguez (Author), Adriana Gruppi (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: B cells and antibodies are involved not only in controlling the spread of blood circulating Trypanosoma cruzi, but also in the autoreactive manifestations observed in Chagas disease. Acute infection results in polyclonal B cell activation associated with hypergammaglobulinemia, delayed s...