Hydrogen Peroxide Is Responsible for the Cytotoxic Effects of Streptococcus pneumoniae on Primary Microglia in the Absence of Pneumolysin

• Main Authors: Franziska Jennert (Author), Désirée Schaaf (Author), Roland Nau (Author), Thomas P. Kohler (Author), Sven Hammerschmidt (Author), Darius Häusler (Author), Peter Valentin-Weigand (Author), Jana Seele (Author)
• Format: Book
• Published: Karger Publishers, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Streptococcus pneumoniae is the most common cause of bacterial meningitis and meningoencephalitis in humans. The bacterium produces numerous virulence determinants; among them, hydrogen peroxide (H2O2) and pneumolysin (Ply) contribute to bacterial cytotoxicity. Microglia, the resident...