Development and validation of an HPLC method for the simultaneous determination of artesunate and mefloquine hydrochloride in fixed-dose combination tablets

• Hauptverfasser: Fernando Henrique Andrade Nogueira (Verfasst von), Naialy Fernandes Araújo Reis (Verfasst von), Paula Rocha Chellini (Verfasst von), Isabela da Costa César (Verfasst von), Gerson Antônio Pianetti (Verfasst von)
• Format: Buch
• Veröffentlicht: Universidade de São Paulo, 2013-12-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

The present study developed and validated an HPLC method for the simultaneous determination of artesunate (AS) and mefloquine hydrochloride (MQ) in fixed-dose combination tablets, according to ICH guidelines. The chromatographic separation was carried out on an XBridge C18 (250 x 4.6 mm i.d., 5 µm p...