Development and validation of an HPLC method for the simultaneous determination of artesunate and mefloquine hydrochloride in fixed-dose combination tablets

• Main Authors: Fernando Henrique Andrade Nogueira (Author), Naialy Fernandes Araújo Reis (Author), Paula Rocha Chellini (Author), Isabela da Costa César (Author), Gerson Antônio Pianetti (Author)
• Format: Book
• Published: Universidade de São Paulo, 2013-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study developed and validated an HPLC method for the simultaneous determination of artesunate (AS) and mefloquine hydrochloride (MQ) in fixed-dose combination tablets, according to ICH guidelines. The chromatographic separation was carried out on an XBridge C18 (250 x 4.6 mm i.d., 5 µm p...