Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin

• Main Authors: Vanessa Byles (Author), Yann Cormerais (Author), Krystle Kalafut (Author), Victor Barrera (Author), James E. Hughes Hallett (Author), Shannan Ho Sui (Author), John M. Asara (Author), Christopher M. Adams (Author), Gerta Hoxhaj (Author), Issam Ben-Sahra (Author), Brendan D. Manning (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The mechanistic target of rapamycin complex 1 (mTORC1) is dynamically regulated by fasting and feeding cycles in the liver to promote protein and lipid synthesis while suppressing autophagy. However, beyond these functions, the metabolic response of the liver to feeding and insulin signal...