Optimization of the Pharmacokinetic Profile of [<sup>99m</sup>Tc]Tc-N<sub>4</sub>-Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence

Optimization of the Pharmacokinetic Profile of [<sup>99m</sup>Tc]Tc-N<sub>4</sub>-Bombesin Derivatives by Modification of the Pharmacophoric Gln-Trp Sequence

Current radiolabeled gastrin-releasing peptide receptor (GRPR) ligands usually suffer from high accumulation in GRPR-positive organs (pancreas, stomach), limiting tumor-to-background contrast in the abdomen. In novel N<sub>4</sub>-bombesin derivatives this was addressed by substitutions...

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Main Authors: Thomas Günther (Author), Matthias Konrad (Author), León Stopper (Author), Jan-Philip Kunert (Author), Sebastian Fischer (Author), Roswitha Beck (Author), Angela Casini (Author), Hans-Jürgen Wester (Author)
Format: Book
Published: MDPI AG, 2022-09-01T00:00:00Z.
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