Insulin resistance per se drives early and reversible dysbiosis-mediated gut barrier impairment and bactericidal dysfunction

• Main Authors: Dalale Gueddouri (Author), Michèle Caüzac (Author), Véronique Fauveau (Author), Fadila Benhamed (Author), Wafa Charifi (Author), Lucie Beaudoin (Author), Matthieu Rouland (Author), Florian Sicherre (Author), Agnès Lehuen (Author), Catherine Postic (Author), Gaëlle Boudry (Author), Anne-Françoise Burnol (Author), Sandra Guilmeau (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: A common feature of metabolic diseases is their association with chronic low-grade inflammation. While enhanced gut permeability and systemic bacterial endotoxin translocation have been suggested as key players of this metaflammation, the mechanistic bases underlying these features upon t...