Fyn Kinase-Mediated PKCδ Y311 Phosphorylation Induces Dopaminergic Degeneration in Cell Culture and Animal Models: Implications for the Identification of a New Pharmacological Target for Parkinson's Disease

• Main Authors: Hariharan Saminathan (Author), Anamitra Ghosh (Author), Danhui Zhang (Author), Chunjuan Song (Author), Huajun Jin (Author), Vellareddy Anantharam (Author), Arthi Kanthasamy (Author), Anumantha G. Kanthasamy (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Oxidative stress, neuroinflammation and apoptosis are some of the key etiological factors responsible for dopamin(DA)ergic degeneration during Parkinson's disease (PD), yet the downstream molecular mechanisms underlying neurodegeneration are largely unknown. Recently, a genome-wide association...