Formononetin reverses Treg/Th17 imbalance in immune-mediated bone marrow failure mice by regulating the PI3K/Akt signaling pathway

Abstract Background Severe aplastic anemia (SAA) is a syndrome of bone marrow failure which is life-threatening. Recent studies have demonstrated that CD4 + T cell subsets, including T regulatory (Treg) and T helper 17 (Th17) cells, play a pivotal role in the pathogenesis of SAA. Formononetin (FMN)...

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Main Authors: Huixuan Lan (Author), Wei Qiu (Author), Jie Wu (Author), Zhijing Hu (Author), Xiaomin Zhang (Author), Lingling Zhu (Author)
Format: Book
Published: BMC, 2024-03-01T00:00:00Z.
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