MLH1 germline mutation associated with Lynch syndrome in a family followed for more than 45 years

• मुख्य लेखकों: Tomoyuki Momma (लेखक), Kenji Gonda (लेखक), Yoshinori Akama (लेखक), Eisei Endo (लेखक), Daisuke Ujiie (लेखक), Shotaro Fujita (लेखक), Yuko Maejima (लेखक), Shoichiro Horita (लेखक), Kenju Shimomura (लेखक), Shigehira Saji (लेखक), Koji Kono (लेखक), Rei Yashima (लेखक), Fumiaki Watanabe (लेखक), Kokichi Sugano (लेखक), Tadashi Nomizu (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2019-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Lynch syndrome, is an autosomal dominantly inherited disease that predisposes individuals to a high risk of colorectal cancers, and some mismatch-repair genes have been identified as causative genes. The purpose of this study was to investigate the genomic rearrangement of the ge...