Implications for the metabolic fate of oral glutamine supplementation within plasma and erythrocytes of patients with sickle cell disease: A pharmacokinetics study

• Main Authors: Claudia R. Morris (Author), Frans A. Kuypers (Author), Robert Hagar (Author), Sandra Larkin (Author), Lisa Lavrisha (Author), Augusta Saulys (Author), Elliott P. Vichinsky (Author), Jung H. Suh (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: L-Glutamine is FDA-approved for sickle cell disease (SCD), yet the mechanism(s)-of-action are poorly understood. We performed a pharmacokinetics (pK) study to determine the metabolic fate of glutamine supplementation on plasma and erythrocyte amino acids in patients with SCD. Design: A p...