Scavenging dicarbonyls with 5'-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance

• Main Authors: Jiansheng Huang (Author), Huan Tao (Author), Patricia G. Yancey (Author), Zoe Leuthner (Author), Linda S. May-Zhang (Author), Ju-Yang Jung (Author), Youmin Zhang (Author), Lei Ding (Author), Venkataraman Amarnath (Author), Dianxin Liu (Author), Sheila Collins (Author), Sean S. Davies (Author), MacRae F. Linton (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Oxidative stress contributes to the development of insulin resistance (IR) and atherosclerosis. Peroxidation of lipids produces reactive dicarbonyls such as Isolevuglandins (IsoLG) and malondialdehyde (MDA) that covalently bind plasma/cellular proteins, phospholipids, and DNA leading to a...