BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements

• Main Authors: Sara El Ashkar (Author), Jan De Rijck (Author), Jonas Demeulemeester (Author), Sofie Vets (Author), Paradise Madlala (Author), Katerina Cermakova (Author), Zeger Debyser (Author), Rik Gijsbers (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Stable integration in the host genome renders murine leukemia virus (MLV)-derived vectors attractive tools for gene therapy. Adverse events in otherwise successful clinical trials caused by proto-oncogene activation due to vector integration hamper their application. MLV and MLV-based vectors integr...