BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements

• Główni autorzy: Sara El Ashkar (Autor), Jan De Rijck (Autor), Jonas Demeulemeester (Autor), Sofie Vets (Autor), Paradise Madlala (Autor), Katerina Cermakova (Autor), Zeger Debyser (Autor), Rik Gijsbers (Autor)
• Format: Książka
• Wydane: Elsevier, 2014-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Stable integration in the host genome renders murine leukemia virus (MLV)-derived vectors attractive tools for gene therapy. Adverse events in otherwise successful clinical trials caused by proto-oncogene activation due to vector integration hamper their application. MLV and MLV-based vectors integr...