BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements

• Автори: Sara El Ashkar (Автор), Jan De Rijck (Автор), Jonas Demeulemeester (Автор), Sofie Vets (Автор), Paradise Madlala (Автор), Katerina Cermakova (Автор), Zeger Debyser (Автор), Rik Gijsbers (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2014-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Stable integration in the host genome renders murine leukemia virus (MLV)-derived vectors attractive tools for gene therapy. Adverse events in otherwise successful clinical trials caused by proto-oncogene activation due to vector integration hamper their application. MLV and MLV-based vectors integr...