Effects of K-877, a novel selective PPARα modulator, on small intestine contribute to the amelioration of hyperlipidemia in low-density lipoprotein receptor knockout mice

• Main Authors: Kenta Takei (Author), Yoshimi Nakagawa (Author), Yunong Wang (Author), Song-iee Han (Author), Aoi Satoh (Author), Motohiro Sekiya (Author), Takashi Matsuzaka (Author), Hitoshi Shimano (Author)
• Format: Book
• Published: Elsevier, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peroxisome proliferator-activated receptor α (PPARα) is a well-known therapeutic target for treating hyperlipidemia. K-877 is a novel selective PPARα modulator (SPPARMα) that enhances PPARα transcriptional activity with high selectivity and potency, resulting in reduced plasma lipid levels. This stu...