DDAH1 Protects against Acetaminophen-Induced Liver Hepatoxicity in Mice

• Main Authors: Xiyue Shen (Author), Saddam Muhammad Ishaq (Author), Qiao'e Wang (Author), Juntao Yuan (Author), Junling Gao (Author), Zhongbing Lu (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In many developed countries, acetaminophen (APAP) overdose-induced acute liver injury is a significant therapeutic problem. Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is a critical enzyme for asymmetric dimethylarginine (ADMA) metabolism. Growing evidence suggests that liver dysfunction is as...