Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model

• Asıl Yazarlar: Yang Liu (Yazar), Xiaoruo Zhu (Yazar), Shiliang Ji (Yazar), Zhen Huang (Yazar), Yuhui Zang (Yazar), Ying Ding (Yazar), Junfeng Zhang (Yazar), Zhi Ding (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Colchicine (Col) is used to prevent and treat acute gout flare; however, its therapeutic use is strictly limited owing to severe gastrointestinal side effects after oral administration. Therefore, we developed a dissolvable Col-loaded microneedle (MN) with hyaluronic acid to deliver Col via the tran...