Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model

• Main Authors: Yang Liu (Author), Xiaoruo Zhu (Author), Shiliang Ji (Author), Zhen Huang (Author), Yuhui Zang (Author), Ying Ding (Author), Junfeng Zhang (Author), Zhi Ding (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colchicine (Col) is used to prevent and treat acute gout flare; however, its therapeutic use is strictly limited owing to severe gastrointestinal side effects after oral administration. Therefore, we developed a dissolvable Col-loaded microneedle (MN) with hyaluronic acid to deliver Col via the tran...