Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni.

• Main Authors: Julien Portela (Author), Jérôme Boissier (Author), Benjamin Gourbal (Author), Vincent Pradines (Author), Vincent Collière (Author), Frédéric Coslédan (Author), Bernard Meunier (Author), Anne Robert (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosomiasis is among the most neglected tropical diseases, since its mode of spreading tends to limit the contamination to people who are in contact with contaminated waters in endemic countries. Here we report the in vitro and in vivo anti-schistosomal activities of trioxaquines. These hybrid m...