PfMDR1 Transport Rates Assessed in Intact Isolated <i>Plasmodium falciparum</i> Digestive Vacuoles Reflect Functional Drug Resistance Relationship with <i>pfmdr1</i> Mutations

• Main Authors: Nina Simon (Author), Cornelia Voigtländer (Author), Barbara Kappes (Author), Petra Rohrbach (Author), Oliver Friedrich (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2022-02-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Drug resistance often emerges from mutations in solute transporters. Single amino acid exchanges may alter functionality of transporters with 'de novo' ability to transport drugs away from their site of action. The PfMDR1 transporter (or P-glycoprotein 1) is located in the membrane of the...