A Riboswitch-Driven Era of New Antibacterials

• Main Authors: Nikoleta Giarimoglou (Author), Adamantia Kouvela (Author), Alexandros Maniatis (Author), Athanasios Papakyriakou (Author), Jinwei Zhang (Author), Vassiliki Stamatopoulou (Author), Constantinos Stathopoulos (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Riboswitches are structured non-coding RNAs found in the 5' UTR of important genes for bacterial metabolism, virulence and survival. Upon the binding of specific ligands that can vary from simple ions to complex molecules such as nucleotides and tRNAs, riboswitches change their local and global...