Sphenopalatine Ganglion Stimulation Upregulates Transport of Temozolomide across the Blood-Brain Barrier

• Main Authors: Thana N. Theofanis (Author), Ankit K. Rochani (Author), Richard F. Schmidt (Author), Michael J. Lang (Author), Geoffrey P. Stricsek (Author), Robert H. Rosenwasser (Author), Ashwini D. Sharan (Author), Gagan Kaushal (Author), Lorraine Iacovitti (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sphenopalatine ganglion (SPG) stimulation has been shown to reversibly alter blood-brain barrier (BBB) permeability. It is widely used for the treatment of cluster headaches in Europe and is well tolerated in humans. The therapeutic potential for SPG stimulation in other central nervous system (CNS)...