Strategic application of CuAAC click chemistry in the modification of natural products for anticancer activity

• Main Authors: Zaozao Xiao (Author), Yuang Gu (Author), Hewei Dong (Author), Bo Liu (Author), Weiwei Jin (Author), Jie Li (Author), Peixiang Ma (Author), Hongtao Xu (Author), Wei Hou (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Natural products play a key role in the history of human drug discovery, and especially for the anticancer agents. Copper(I)-catalyzed alkyne-azide [3+2] cycloaddition (CuAAC) reaction is perhaps the most powerful method for the efficient modification of complex natural products, enabling the direct...