Strategic application of CuAAC click chemistry in the modification of natural products for anticancer activity

• Главные авторы: Zaozao Xiao (Автор), Yuang Gu (Автор), Hewei Dong (Автор), Bo Liu (Автор), Weiwei Jin (Автор), Jie Li (Автор), Peixiang Ma (Автор), Hongtao Xu (Автор), Wei Hou (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2023-12-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Natural products play a key role in the history of human drug discovery, and especially for the anticancer agents. Copper(I)-catalyzed alkyne-azide [3+2] cycloaddition (CuAAC) reaction is perhaps the most powerful method for the efficient modification of complex natural products, enabling the direct...