Thermal proteome profiling reveals Haemonchus orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868

• Main Authors: Aya C. Taki (Author), Tao Wang (Author), Nghi N. Nguyen (Author), Ching-Seng Ang (Author), Michael G. Leeming (Author), Shuai Nie (Author), Joseph J. Byrne (Author), Neil D. Young (Author), Yuanting Zheng (Author), Guangxu Ma (Author), Pasi K. Korhonen (Author), Anson V. Koehler (Author), Nicholas A. Williamson (Author), Andreas Hofmann (Author), Bill C. H. Chang (Author), Cécile Häberli (Author), Jennifer Keiser (Author), Abdul Jabbar (Author), Brad E. Sleebs (Author), Robin B. Gasser (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. The control of these parasites relies heavily on anthelmintic therapy, but treatment failures and resistance to these drugs are widespread. As efforts to develop vaccines...