On-target and direct modulation of alloreactive T cells by a nanoparticle carrying MHC alloantigen, regulatory molecules and CD47 in a murine model of alloskin transplantation

• Main Authors: Khawar Ali Shahzad (Author), Xin Wan (Author), Lei Zhang (Author), Weiya Pei (Author), Aifeng Zhang (Author), Muhammad Younis (Author), Wei Wang (Author), Chuanlai Shen (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Biomimetic nanoparticles have been reported as immune modulators in autoimmune diseases and allograft rejections by numerous researchers. However, most of the therapeutics carrying antigens, toxins or cytokines underlay the mechanism of antigen presentation by cellular uptake of NPs through pinocyto...