Predicted neoantigen load in non-hypermutated endometrial cancers: Correlation with outcome and tumor-specific genomic alterations

• Main Authors: Sachet A. Shukla (Author), Brooke E. Howitt (Author), Catherine J. Wu (Author), Panagiotis A. Konstantinopoulos (Author)
• 格式: 图书
• 出版: Elsevier, 2017-02-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Elevated neoantigen load has been previously correlated with improved outcome and response to immune checkpoint blockade in various tumor types. In endometrial cancer, previous studies of neoantigen load prediction have shown that the hypermutated MSI and POLE-mutated tumors harbor significantly hig...