Predicted neoantigen load in non-hypermutated endometrial cancers: Correlation with outcome and tumor-specific genomic alterations

• Главные авторы: Sachet A. Shukla (Автор), Brooke E. Howitt (Автор), Catherine J. Wu (Автор), Panagiotis A. Konstantinopoulos (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2017-02-01T00:00:00Z.
• Предметы: article
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Elevated neoantigen load has been previously correlated with improved outcome and response to immune checkpoint blockade in various tumor types. In endometrial cancer, previous studies of neoantigen load prediction have shown that the hypermutated MSI and POLE-mutated tumors harbor significantly hig...