Comparison of 4 Screening Methods for Detecting Fluoropyrimidine Toxicity Risk: Identification of the Most Effective, Cost-Efficient Method to Save Lives

• Main Authors: Olivier Capitain (Author), Valérie Seegers (Author), Jean-Philippe Metges (Author), Roger Faroux (Author), Claire Stampfli (Author), Marc Ferec (Author), Tamara Matysiak Budnik (Author), Hélène Senellart (Author), Valérie Rossi (Author), Nadège Blouin (Author), Jonathan Dauvé (Author), Mario Campone (Author)
• Format: Book
• Published: SAGE Publishing, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Fluoropyrimidines (FPs) carry around 20% risk of G3-5 toxicity and 0.2-1% risk of death, due to dihydropyrimidine dehydrogenase (DPD) deficiency. Several screening approaches exist for predicting toxicity, however there is ongoing debate over which method is best. This study compares 4 s...