Application of 1-Hydroxy-4,5-Dimethyl-Imidazole 3-Oxide as Coformer in Formation of Pharmaceutical Cocrystals

• Main Authors: Aneta Wróblewska (Author), Justyna Śniechowska (Author), Sławomir Kaźmierski (Author), Ewelina Wielgus (Author), Grzegorz D. Bujacz (Author), Grzegorz Mlostoń (Author), Arkadiusz Chworos (Author), Justyna Suwara (Author), Marek J. Potrzebowski (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Two, well defined binary crystals with 1-Hydroxy-4,5-Dimethyl-Imidazole 3-Oxide (HIMO) as coformer and thiobarbituric acid (TBA) as well barbituric acid (BA) as Active Pharmaceutical Ingredients (APIs) were obtained by cocrystallization (from methanol) or mechanochemically by grinding. The progress...