Daily administration of yokukansan and keishito prevents social isolation-induced behavioral abnormalities and down-regulation of phosphorylation of neuroplasticity-related signaling molecules in mice

• Main Authors: Hironori Fujiwara (Author), Yaoyu Han (Author), Ken Ebihara (Author), Suresh Awale (Author), Ryota Araki (Author), Takeshi Yabe (Author), Kinzo Matsumoto (Author)
• Format: Book
• Published: BMC, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Our previous studies demonstrated that post-weaning social isolation (ISO) in mice induces behavior abnormalities such as deficits of sociability- and attention-like behaviors. These deficits can be attenuated by methylphenidate (MPH), a drug used for attention deficit hyperactiv...