Daily administration of yokukansan and keishito prevents social isolation-induced behavioral abnormalities and down-regulation of phosphorylation of neuroplasticity-related signaling molecules in mice

• Autori principali: Hironori Fujiwara (Autore), Yaoyu Han (Autore), Ken Ebihara (Autore), Suresh Awale (Autore), Ryota Araki (Autore), Takeshi Yabe (Autore), Kinzo Matsumoto (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2017-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background Our previous studies demonstrated that post-weaning social isolation (ISO) in mice induces behavior abnormalities such as deficits of sociability- and attention-like behaviors. These deficits can be attenuated by methylphenidate (MPH), a drug used for attention deficit hyperactiv...