Safety and immunogenicity of rSh28GST antigen in humans: phase 1 randomized clinical study of a vaccine candidate against urinary schistosomiasis.

• Main Authors: Gilles Riveau (Author), Dominique Deplanque (Author), Franck Remoué (Author), Anne-Marie Schacht (Author), Hubert Vodougnon (Author), Monique Capron (Author), Michel Thiry (Author), Joseph Martial (Author), Christian Libersa (Author), André Capron (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment of urinary schistosomiasis by chemotherapy remains challenging due to rapid re-infection and possibly to limited susceptibility to praziquantel treatment. Therefore, therapeutic vaccines represent an attractive alternative control strategy. The objectives of this study were to assess the s...