Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction

• Автори: Zorik Chilingaryan (Автор), Stephen J. Headey (Автор), Allen T. Y. Lo (Автор), Zhi-Qiang Xu (Автор), Gottfried Otting (Автор), Nicholas E. Dixon (Автор), Martin J. Scanlon (Автор), Aaron J. Oakley (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2018-02-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

In bacteria, the DnaG primase is responsible for synthesis of short RNA primers used to initiate chain extension by replicative DNA polymerase(s) during chromosomal replication. Among the proteins with which Escherichia coli DnaG interacts is the single-stranded DNA-binding protein, SSB. The C-termi...