Impaired muscle morphology in a Drosophila model of myosin storage myopathy was suppressed by overexpression of an E3 ubiquitin ligase

• Main Authors: Martin Dahl-Halvarsson (Author), Montse Olive (Author), Malgorzata Pokrzywa (Author), Michaela Norum (Author), Katarina Ejeskär (Author), Homa Tajsharghi (Author)
• Format: Book
• Published: The Company of Biologists, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Myosin is vital for body movement and heart contractility. Mutations in MYH7, encoding slow/β-cardiac myosin heavy chain, are an important cause of hypertrophic and dilated cardiomyopathy, as well as skeletal muscle disease. A dominant missense mutation (R1845W) in MYH7 has been reported in several...