Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques.

Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques.

Dengue virus (DENV) is transmitted by infectious mosquitoes during blood-feeding via saliva containing biologically-active proteins. Here, we examined the effect of varying DENV infection modality in rhesus macaques in order to improve the DENV nonhuman primate (NHP) challenge model. NHPs were expos...

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Main Authors: Michael K McCracken (Author), Gregory D Gromowski (Author), Lindsey S Garver (Author), Brad A Goupil (Author), Kathryne D Walker (Author), Heather Friberg (Author), Jeffrey R Currier (Author), Wiriya Rutvisuttinunt (Author), Kevin L Hinton (Author), Rebecca C Christofferson (Author), Christopher N Mores (Author), Yannick Vanloubbeeck (Author), Clarisse Lorin (Author), Marie-Pierre Malice (Author), Stephen J Thomas (Author), Richard G Jarman (Author), David W Vaughn (Author), J Robert Putnak (Author), Lucile Warter (Author)
Format: Book
Published: Public Library of Science (PLoS), 2020-04-01T00:00:00Z.
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3rd Floor Main Library

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