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Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques.

Dengue virus (DENV) is transmitted by infectious mosquitoes during blood-feeding via saliva containing biologically-active proteins. Here, we examined the effect of varying DENV infection modality in rhesus macaques in order to improve the DENV nonhuman primate (NHP) challenge model. NHPs were expos...

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Main Authors: Michael K McCracken (Author), Gregory D Gromowski (Author), Lindsey S Garver (Author), Brad A Goupil (Author), Kathryne D Walker (Author), Heather Friberg (Author), Jeffrey R Currier (Author), Wiriya Rutvisuttinunt (Author), Kevin L Hinton (Author), Rebecca C Christofferson (Author), Christopher N Mores (Author), Yannick Vanloubbeeck (Author), Clarisse Lorin (Author), Marie-Pierre Malice (Author), Stephen J Thomas (Author), Richard G Jarman (Author), David W Vaughn (Author), J Robert Putnak (Author), Lucile Warter (Author)
Format: Book
Published: Public Library of Science (PLoS), 2020-04-01T00:00:00Z.
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