Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFRWT and EGFRT790M

Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFRWT and EGFRT790M

New 1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesised to act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives were assessed for their in vitro anti-proliferative activities against A549 and HCT-116 cancer cells. Compounds 8, 10, 12a, and 12b s...

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Main Authors: Ahmed A. Gaber (Author), Mohamed Sobhy (Author), Abdallah Turky (Author), Hanan Gaber Abdulwahab (Author), Ahmed A. Al-Karmalawy (Author), Mostafa. A. Elhendawy (Author), Mohamed. M. Radwan (Author), Eslam B. Elkaeed (Author), Ibrahim M. Ibrahim (Author), Heba S. A. Elzahabi (Author), Ibrahim H. Eissa (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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