Discovery of new 1H-pyrazolo[3,4-d]pyrimidine derivatives as anticancer agents targeting EGFRWT and EGFRT790M

• Κύριοι συγγραφείς: Ahmed A. Gaber (Συγγραφέας), Mohamed Sobhy (Συγγραφέας), Abdallah Turky (Συγγραφέας), Hanan Gaber Abdulwahab (Συγγραφέας), Ahmed A. Al-Karmalawy (Συγγραφέας), Mostafa. A. Elhendawy (Συγγραφέας), Mohamed. M. Radwan (Συγγραφέας), Eslam B. Elkaeed (Συγγραφέας), Ibrahim M. Ibrahim (Συγγραφέας), Heba S. A. Elzahabi (Συγγραφέας), Ibrahim H. Eissa (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

New 1H-pyrazolo[3,4-d]pyrimidine derivatives were designed and synthesised to act as epidermal growth factor receptor inhibitors (EGFRIs). The synthesised derivatives were assessed for their in vitro anti-proliferative activities against A549 and HCT-116 cancer cells. Compounds 8, 10, 12a, and 12b s...