Local application of engineered insulin-like growth factor I mRNA demonstrates regenerative therapeutic potential in vivo

• Main Authors: Justin S. Antony (Author), Pascale Birrer (Author), Claudia Bohnert (Author), Sina Zimmerli (Author), Petra Hillmann (Author), Hervé Schaffhauser (Author), Christine Hoeflich (Author), Andreas Hoeflich (Author), Ramzi Khairallah (Author), Andreas T. Satoh (Author), Isabelle Kappeler (Author), Isabel Ferreira (Author), Klaas P. Zuideveld (Author), Friedrich Metzger (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Insulin-like growth factor I (IGF-I) is a growth-promoting anabolic hormone that fosters cell growth and tissue homeostasis. IGF-I deficiency is associated with several diseases, including growth disorders and neurological and musculoskeletal diseases due to impaired regeneration. Despite the vast r...