PGC-1α-Dependent Mitochondrial Adaptation Is Necessary to Sustain IL-2-Induced Activities in Human NK Cells

• Main Authors: Dante Miranda (Author), Claudia Jara (Author), Jorge Ibañez (Author), Viviana Ahumada (Author), Claudio Acuña-Castillo (Author), Adrian Martin (Author), Alexandra Córdova (Author), Margarita Montoya (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human Natural Killer (NK) cells are a specialized heterogeneous subpopulation of lymphocytes involved in antitumor defense reactions. NK cell effector functions are critically dependent on cytokines and metabolic activity. Among various cytokines modulating NK cell function, interleukin-2 (IL-2) can...